Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpA sites 1 1 Edited by J. Karn

By H. Gowher, Albert Jeltsch. 2001

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5-Azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy (2002, background): “…3b could be much more sensitive to the inhibitory effects of ZCyt and DZCyt incorporated into DNA since they are randomly incorporated in place of Cyt and, unlike Dnmt1, Dnmt3a and 3b are capable of methylating Cyt residues that are not in CpG sites (Aoki et al., 2001; Gowher and Jeltsch, 2001).”
DNA methylation patterns and epigenetic memory. (2002, background): “Although there is evidence for non-CpG methylation in ES cells, most probably owing to DNMT3A, which strongly methylates CpA as well as CpG (Ramsahoye et al. 2000; Gowher and Jeltsch 2001), non-CpG methylation is barely detectable in adult cells (Ramsahoye et al. 2000).”