Leptospira: The Dawn of the Molecular Genetics Era for an Emerging Zoonotic Pathogen
By A. Ko, C. Goarant, M. Picardeau. Nature Reviews Microbiology, 2009
805 citations recorded by the source corpus.
Leptospirosis is a zoonotic disease that has emerged as an important cause of morbidity and mortality among impoverished populations. One hundred years after the discovery of the causative spirochaetal agent, little is understood about Leptospira spp. pathogenesis, which in turn has hampered the development of new intervention strategies to address this neglected disease. However, the recent availability of complete genome sequences for Leptospira spp. and the discovery of genetic tools for their transformation have led to important insights into the biology of these pathogens and their pathogenesis. We discuss the life cycle of the bacterium, the recent advances in our understanding and the implications for the future prevention of leptospirosis.
Subfields: Parasitology
View Paper: https://www.semanticscholar.org/paper/9cca4adc1cf4e1da300ab979f2318e343f3a7814
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Citations in the corpus
- Global Morbidity and Mortality of Leptospirosis: A Systematic Review (2015, background): “The disease has a broad geographical distribution due to the large spectrum of mammalian hosts that harbour and excrete the spirochete agent from their renal tubules [1,3,7].”
- Leptospirosis in Humans (2015, positive): “However, the results justify further attempts to understand the role of amphibians in maintaining leptospires in nature (Adler and de la Peña-Moctezuma 2010; Bharti et al. 2003; Hartskeerl et al. 2011; Ko et al. 2009; Levett 2001; McBride et al. 2005; Felzemburgh et al. 2014).”