Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure.

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Accurate prediction of protein structures and interactions using a 3-track neural network (2021, positive): “…thrombospondin motifs) families of metalloproteases are encoded by more than 40 human genes, mediate cell-cell and cell-matrix interactions ( 20 , 21 ), and are involved in a range of human diseases, including cancer metastasis, inflammatory disorders, neurological diseases, and asthma ( 21 , 22 ).”
A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “There are 22 ADAMs in human [62], 14 of these ADAMs including ADAM-1, 2, 3, 6, 7, 18, 20, 21, 22, 28, 29, 30, 32 and 33 are restricted to embryo development, and are mainly expressed and conduct their function in the reproductive system such as testis, epididymis and uterus.”
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade (2013, background): “…e.g. serine proteinases and thiol proteases (Barrett et al., 2012), other subfamilies, including, A disintegrin and metalloproteinases (ADAMs) (Klein & Bischoff, 2011; Murphy, 2008) and a disintegrin and MMP with thrombospondin motifs (ADAMTSs) (Apte, 2009) and unique members such as t-PA.”