Multiple Time Scales of Adaptation in Auditory Cortex Neurons
By Nachum Ulanovsky, Liora Las, Dina Farkas, Israel Nelken. Journal of Neuroscience, 2004
707 citations recorded by the source corpus.
Neurons in primary auditory cortex (A1) of cats show strong stimulus-specific adaptation (SSA). In probabilistic settings, in which one stimulus is common and another is rare, responses to common sounds adapt more strongly than responses to rare sounds. This SSA could be a correlate of auditory sensory memory at the level of single A1 neurons. Here we studied adaptation in A1 neurons, using three different probabilistic designs. We showed that SSA has several time scales concurrently, spanning many orders of magnitude, from hundreds of milliseconds to tens of seconds. Similar time scales are known for the auditory memory span of humans, as measured both psychophysically and using evoked potentials. A simple model, with linear dependence on both short-term and long-term stimulus history, provided a good fit to A1 responses. Auditory thalamus neurons did not show SSA, and their responses were poorly fitted by the same model. In addition, SSA increased the proportion of failures in the responses of A1 neurons to the adapting stimulus. Finally, SSA caused a bias in the neuronal responses to unbiased stimuli, enhancing the responses to eccentric stimuli. Therefore, we propose that a major function of SSA in A1 neurons is to encode auditory sensory memory on multiple time scales. This SSA might play a role in stream segregation and in binding of auditory objects over many time scales, a property that is crucial for processing of natural auditory scenes in cats and of speech and music in humans.
Subfields: Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/9c7f38e63e1b59a0298c60c3dd5e39f052e4a7d6
How researchers see this paper
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In Cognitive Neuroscience
- Jean-Pierre Changeux
- Torsten Baldeweg
- Stanislas Dehaene
- Elyse S. Sussman
- Israel Nelken
- Nachum Ulanovsky
- Catherine Wacongne
- Leonardo G. Cohen
Citations in the corpus
- ERP Repetition Effects and Mismatch Negativity Generation A Predictive Coding Perspective (2007, background): “Again, there are parallels with neuronal adaptation (SSA) effects in A1 lasting over multiple, nested time-scales of similar duration (Ulanovsky et al., 2004).”
- A New View on the MMN and Attention Debate The Role of Context in Processing Auditory Events (2007, result): “With these changes to the paradigm, the frequency MMN in the unattended ear was abolished but the intensity MMN in the unattended ear was unaffected (see Figure 6), consistent with the competition hypothesis (see also Deouell, this issue[not listed in refs]; Shalgi & Deouell, 2007). Shalgi & Deouell”
- A Neuronal Model of Predictive Coding Accounting for the Mismatch Negativity (2012, background): “However, experimentally, the recovery time of synaptic depression is generally of the order of a few seconds (Varela et al., 1997; Ulanovsky et al., 2004).”
- Mismatch Negativity and Stimulus-Specific Adaptation in Animal Models (2007, methodology): “These frequency ratios are substantially smaller than the width of frequency tuning curves of auditory cortex neurons (Ulanovsky et al., 2004; Moshitch, Las, Ulanovsky, Bar-Yosef, & Nelken, 2006), and also smaller than the width of peripheral tuning curves in the cat (Liberman, 1978).”