Platelet rich plasma injection grafts for musculoskeletal injuries: a review
By S. Sampson, Michael B. Gerhardt, B. Mandelbaum. Current Reviews in Musculoskeletal Medicine, 2008
630 citations recorded by the source corpus.
In Europe and the United States, there is an increasing prevalence of the use of autologous blood products to facilitate healing in a variety of applications. Recently, we have learned more about specific growth factors, which play a crucial role in the healing process. With that knowledge there is abundant enthusiasm in the application of concentrated platelets, which release a supra-maximal quantity of these growth factors to stimulate recovery in non-healing injuries. For 20 years, the application of autologous PRP has been safely used and documented in many fields including; orthopedics, sports medicine, dentistry, ENT, neurosurgery, ophthalmology, urology, wound healing, cosmetic, cardiothoracic, and maxillofacial surgery. This article introduces the reader to PRP therapy and reviews the current literature on this emerging treatment modality. In summary, PRP provides a promising alternative to surgery by promoting safe and natural healing. However, there are few controlled trials, and mostly anecdotal or case reports. Additionally the sample sizes are frequently small, limiting the generalization of the findings. Recently, there is emerging literature on the beneficial effects of PRP for chronic non-healing tendon injuries including lateral epicondylitis and plantar fasciitis and cartilage degeneration (Mishra and Pavelko, The American Journal of Sports Medicine 10(10):1–5, 2006; Barrett and Erredge, Podiatry Today 17:37–42, 2004). However, as clinical use increases, more controlled studies are needed to further understand this treatment.
Subfields: Orthopedics and Sports Medicine, Surgery, Urology
View Paper: https://www.semanticscholar.org/paper/9c7877183f9d9a705cf133acff27df021f204bcd
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In Orthopedics and Sports Medicine
In Surgery
In Urology
Citations in the corpus
- Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. (2010, positive): “Platelets derived from whole blood using simple cell-separating systems provide a release of various growth factors that participate in tissue repair processes.(9,12,13) Three recent reviews reported promising results of the use of PRP in tendinopathy, although these conclusions were based on labora”
- Bone grafts and biomaterials substitutes for bone defect repair: A review (2017, neutral): “It activates CaSR and downstream signaling pathw OPG production and decreases RANKL expression. osteoblast proliferation, differentiation, and viabili apoptosis of osteoclasts that result to the decrease Si4þ Angiogenesis, osteogenesis Silicon has been shown to induce angiogenesis by leading to incr”
- Platelet-Rich Plasma (2009, positive): “Despite the lack of any prospective randomized data to guide our decisions regarding PRP, our clinical indications for PRP treatment for patellar tendinosis are as follows: (1) severe symptoms present for more than 3 months that are unresponsive to physical therapy, (2) clinical findings corroborate”
- Positive Effect of an Autologous Platelet Concentrate in Lateral Epicondylitis in a Double-Blind Randomized Controlled Trial (2010, background): “Platelet-rich plasma (PRP) is promoted as an ideal autologous biological blood-derived product that can be exogenously applied to various tissues, where it releases high concentrations of platelet-derived growth factors that enhance wound healing, bone healing, and tendon healing.(14) In addition, P”