hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer

By C. Camps, F. Buffa, Stefano Colella, John W. Moore, C. Sotiriou, H. Sheldon, Adrian L. Harris, J. Gleadle, Jiannis Ragoussis. Clinical Cancer Research, 2008

642 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9c492c17dc8047b8578ac5f8f85f9d2a00fef5bc

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Citations in the corpus

MicroRNAs in development and disease. (2011, background): “Similarly, miR-210, which is induced by hypoxia (72, 171), was sufficient for inducing tubulogenesis in HUVEC cells (171).”
Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation (2009, positive): “864 Molecular Cell 35, 856–867, September 25, 2009 a2009 Elsevie Overexpression of mir-210 has been detected in breast cancer patients recently and was correlated with worse prognosis and was also found correlated to VEGF, hypoxia, and angiogenesis (Camps et al., 2008; Foekens et al., 2008; Zhang et”
Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, background): “However, correlation between these miRNAs and metastasis was not identified in large clinical studies (28, 29).”
Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization (2011, methodology): “1a ), we performed a retrospective analysis on a series of breast tumor samples ( n = 210, Oxford collection”
Hypoxic enhancement of exosome release by breast cancer cells (2012, neutral): “0025) as previously reported [42].”
Anoikis molecular pathways and its role in cancer progression. (2013, background): “This miR has been found expressed in many tumors and its contribution to inhibition of pro-apoptotic signaling in an hypoxic environment is linked to its dependence from HIF-1 [37].”
MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2 (2009, neutral): “Additionally, miR-210 is specifically induced by HIF-1a but not HIF-2a (Camps et al., 2008), a second transcriptional regulator of the hypoxic response, which carries partial but not full redundancy in function with HIF-1a (Wang et al., 2005).”