Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4.

By Shufeng Zhou. Current drug metabolism, 2008

690 citations recorded by the source corpus.

Subfields: Analytical Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/9c2841528d15a1afd0633b84894995a0c4a4aab4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Analytical Chemistry

1. Y. Oron
2. Roded Sharan
3. Eytan Ruppin
4. Gideon Y Stein
5. Assaf Gottlieb

In Pharmacology

1. Y. Oron
2. Roded Sharan
3. Eytan Ruppin
4. Gideon Y Stein
5. Assaf Gottlieb
6. Shufeng Zhou
7. Jun-Ping Liu
8. B. Chowbay

Citations in the corpus

• Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “The plasma concentrations of the parent drug were extremely low in 1 subject with 13 CYP2D6*2 genes, but very high concentrations of 10-hydroxynortriptyline were observed (Dalen et al., 1998).”
• Molecular Systems Biology Peer Review Process File Indi: a Computational Framework for Inferring Drug Interactions and Their Associated Recommendations Transaction Report (positive): “There are three known types of interactions between drugs and CYPs (some drugs interact with a CYP in more than one way): the drug is (i) metabolized by the CYP enzyme (substrates); (ii) inhibits the CYP activity (inhibitor); or (iii) increases the CYP activity (inducer) (Zhou, 2008).”