Adaptable Hydrogel Networks with Reversible Linkages for Tissue Engineering
By Huiyuan Wang, S. Heilshorn. Advances in Materials, 2015
630 citations recorded by the source corpus.
Adaptable hydrogels have recently emerged as a promising platform for three‐dimensional (3D) cell encapsulation and culture. In conventional, covalently crosslinked hydrogels, degradation is typically required to allow complex cellular functions to occur, leading to bulk material degradation. In contrast, adaptable hydrogels are formed by reversible crosslinks. Through breaking and re‐formation of the reversible linkages, adaptable hydrogels can be locally modified to permit complex cellular functions while maintaining their long‐term integrity. In addition, these adaptable materials can have biomimetic viscoelastic properties that make them well suited for several biotechnology and medical applications. In this review, an overview of adaptable‐hydrogel design considerations and linkage selections is presented, with a focus on various cell‐compatible crosslinking mechanisms that can be exploited to form adaptable hydrogels for tissue engineering.
Subfields: Biomedical Engineering, Cell Biology, Molecular Medicine
View Paper: https://www.semanticscholar.org/paper/9bd8d576fd35c9dc31b40bf2553e82ff579ef72e
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- H. Montazerian
- Rohollah Nasiri
- Chun Xu
- A. Khademhosseini
- Nureddin Ashammakhi
- Hyojin Ko
- S. Ahadian
- N. Barros
Citations in the corpus
- Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs (2019, background): “Hence, more attention should be paid to uncover capabilities in programming the cell behavior, controlling the cell spreading and matrix mechanics [262].”