Time cells in the hippocampus: a new dimension for mapping memories

By Howard Eichenbaum. Nature Reviews Neuroscience, 2014

699 citations recorded by the source corpus.

Recent studies have revealed the existence of hippocampal neurons that fire at successive moments in temporally structured experiences. Several studies have shown that such temporal coding is not attributable to external events, specific behaviours or spatial dimensions of an experience. Instead, these cells represent the flow of time in specific memories and have therefore been dubbed 'time cells'. The firing properties of time cells parallel those of hippocampal place cells; time cells thus provide an additional dimension that is integrated with spatial mapping. The robust representation of both time and space in the hippocampus suggests a fundamental mechanism for organizing the elements of experience into coherent memories.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/9b6d25de5fd05ca45e1d8cee13f8a388e0e70b8b

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

What Learning Systems do Intelligent Agents Need? Complementary Learning Systems Theory Updated. (2016, neutral): “…ﬁ nding of ‘ concept ’ cells: hippocampal neurons which come to respond to common features across many events, for example cells for speci ﬁ c odors [111], time-points within an episode [112], attributes of a task [113], and even cells that ﬁ re to any picture or the name of a famous person [114].”
Low-dimensional dynamics for working memory and time encoding (2020, neutral): “76 and 77) and in the striatum (78–80).”
Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events (2015, background): “Converging evidence from human and animal studies point to entorhinal cortical (EC)–hippocampal (HPC) circuits as being critical for episodic memory, and in particular for temporal associative learning (Eichenbaum 2014, MacDonald 2014).”
Episodic Memory and Beyond: The Hippocampus and Neocortex in Transformation (2016, positive): “To account for the first two aspects, based on evidence from time cells (Eichenbaum 2014), investigators have proposed a hippocampal mechanism that could construct a scale-invariant representation of time over hundreds of seconds; this could serve as the contextual/neuronal background in which…”
Multimodal Feature Integration in the Angular Gyrus during Episodic and Semantic Retrieval (2016, background): “Moreover, whereas the hippocampus may integrate elements of an episodic memory such as space and time (Burgess et al., 2002; Eichenbaum, 2014), AnG may integrate sensory elements of multimodal memories into a complete and vivid recollection.”