Amyloids go genomic: Insights regarding the sequence determinants of prion formation from genome-wide studies

By Hilal A. Lashuel, Rohit V. Pappu. 2009

6 citations recorded by the source corpus.

The availability of fully sequenced genomes provides a useful starting point for identifying putative amyloid and prion forming sequences through genome-wide scans. With an inventory in hand, one can assess the amyloid forming potential and the functional consequences of amyloid formation for each sequence. Thus, advancing our understanding of how cells process and utilize deleterious and functional aggregates, respectively.

Subfields: Molecular Biology, Neurology, Physiology