Gold nanoparticles: a new X-ray contrast agent.

By J. Hainfeld, D. Slatkin, T. M. Focella, H. Smilowitz. British Journal of Radiology, 2006

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Size-Dependent Localization and Penetration of Ultrasmall Gold Nanoparticles in Cancer Cells, Multicellular Spheroids, and Tumors in Vivo (2012, positive): “This is consistent with the distribution behavior of 1.9 nm AuNPs.45,46 Over 70% of the injected dose of the 15 nm AuNPs accumulated in the liver and spleen.”
Inorganic Nanoparticles in Cancer Therapy (2010, neutral): “7 g Au/kg) was injected into the tail vein of mice (160).”
Imaging and cancer: A review (2008, background): “…Schellenberger et al., 2002; Harishingani et al., 2003; Li et al., 2004; Kircher et al., 2003), X-ray/CT (Srinivas et al., 2002; Rabin et al., 2006; Hainfeld et al., 2006), optical (Itoh and Osamura, 2007; Gao et al., 2005; Chan et al., 2002; Min-Ho Lee, 2006) and ultrasound imaging (Liu et al.,…”
Gold nanoparticles as novel agents for cancer therapy. (2012, background): “, Yaphank, NY) have been used in vivo, demonstrating longer retention times and superior contrast to iodine with resolution of vessels as small as 100 mm [42].”