Overcoming cellular barriers for RNA therapeutics

By S. Dowdy. Nature Biotechnology, 2017

969 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9aedab538305caca2fb66f993aa8d54071e7f909

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In Molecular Biology

1. Aaron D Springer
2. Min Wu
3. S. Dowdy

Citations in the corpus

• GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics (2018, background): “Fortunately, incorporation of Fluoro (F) and Methoxy (OMe) modifications into the 2¢ position of the ribose ring dramatically reduces both of these activities and, importantly, is highly tolerated by Ago [1–3,6].”
• mRNA-based therapeutics: powerful and versatile tools to combat diseases (2022, background): “Hence, it is quite difficult for mRNA to pass through the anionic cell membrane and translate functional proteins in the cytoplasm (<1/10,000 mRNAs of the initial input).(9) In addition, mRNA can also induce an immune response with associated toxicity, which greatly restricts the development of mRNA”