The role of the Atg1/ULK1 complex in autophagy regulation.

By N. Mizushima. Current Opinion in Cell Biology, 2010

1,076 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9ad41a877459ff998528f11350f35a3962f6f5f7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. E. White
5. Yongqiang Chen
6. Alec C. Kimmelman
7. Xiaohua Li
8. Binyun Ma

In Molecular Biology

1. Beth Levine
2. D. Klionsky
3. N. Mizushima
4. E. White
5. Yongqiang Chen
6. Xiaohua Li
7. Binyun Ma
8. Shi-kun He

Citations in the corpus

• Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease (2010, background): “In addition, mTORC1 inhibits autophagy when nutrients and energy are plentiful through the phosphorylation of Unc51-like kinase 1 (ULK1) and mAtg13, the mammalian homologs of the yeast kinase Atg1 and Atg13 respectively, which are essential for the formation of preautophagosomal structures [14].”
• The regulation of autophagy – unanswered questions (2011, background): “to autophagy induction, whereas ULK1 (or ULK2) still phosphorylates Atg13 and itself, and hyperphosphorylates FIP200 (Chang and Neufeld, 2010; Mizushima, 2010; Yang and Klionsky, 2010).”
• ER stress: Autophagy induction, inhibition and selection (2015, background): “Hence, LC3-II is a marker protein for autophagy detection.(86) Cytosolic autophagosomes need to access lysosomes at the perinuclear region of the cells.”
• Autophagy and the integrated stress response (2010, neutral): “In mice, following starvation for 24–48 hr, most cells in most tissues display increased numbers of autophagosomes (Mizushima, 2010).”
• Principles and Current Strategies for Targeting Autophagy for Cancer Treatment (2011, background): “The ULK1 (ATG1) kinase complex consisting of ULK1 (and/or possibly ULK2), Atg13, and Atg17 integrates stress signals from mTOR complex 1 (mTORC1) and controls the initiation of autophagy (5, 6).”
• Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, neutral): “Defective autophagy pathway or alterations in autophagy-related genes is shown in various human pathologies including neurodegenerative and lysosomal storage disorders as well as in various cancers (Mizushima et al., 2008; Ravikumar et al., 2010).”
• Glycogen and its metabolism: some new developments and old themes. (2012, background): “Subsequent studies of mammalian autophagy showed that AMPK is also a positive regulator of autophagy [226] and, more recently, implicated AMPK as an upstream regulator of ULK1 [227–230], a mammalian orthologue of Atg1p [231].”
• AMPK Activates Autophagy by Phosphorylating ULK1 (2011, neutral): “homolog of yeast Atg17).(8) However, autophagy cannot be”