Early transmissibility assessment of the N501Y mutant strains of SARS-CoV-2 in the United Kingdom, October to November 2020

By K. Leung, M. H. Shum, G. Leung, T. Lam, Joseph T. Wu. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021

619 citations recorded by the source corpus.

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.

Subfields: Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/9aca32aebc2fdf680bd5429eca5b70598c30a209

Citations in the corpus

• SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies (2021, neutral): “V1, emerged in the United Kingdom and was associated with a surge of COVID-19 cases (Kidd et al., 2021; Leung et al., 2021).”