NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling

By S. Kreuz, D. Siegmund, Peter Scheurich, Harald Wajant. Molecular and Cellular Biology, 2001

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Decoding cell death signals in liver inflammation. (2013, background): “In this setting, the NF-jB-mediated transactivation of caspase-8 and FADD-like apoptosis regulator (CFLAR, best known as c-FLIP) blocks cell death signals at the level of TNFR1 [21], hence allowing for the secretion of several pro-inflammatory mediators including interleukin (IL)-6 and IL-8 [20].”
Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. (2003, positive): “FLIPL in se rm -0 05 27 10 5, v er si on 1 - 18 O ct 2 01 0 expression is induced by NF-B (Kreuz et al., 2001; Micheau et al., 2001), which may explain why death receptor-induced apoptosis is generally blocked in cells with active NF-B.”
Necroptosis: a regulated inflammatory mode of cell death (2018, background): “NF-кB signaling plays a key role in counteracting the cytotoxic effect of TNFα, and prosurvival effect of NF-кB is mediated by cIAP1/2 and cFLIPL (cellular FLICE-like inhibitory protein) [29, 30].”