Regulation of immunity and inflammation by hypoxia in immunological niches
By Cormac T. Taylor, S. Colgan. Nature reviews. Immunology, 2017
605 citations recorded by the source corpus.
Immunological niches are focal sites of immune activity that can have varying microenvironmental features. Hypoxia is a feature of physiological and pathological immunological niches. The impact of hypoxia on immunity and inflammation can vary depending on the microenvironment and immune processes occurring in a given niche. In physiological immunological niches, such as the bone marrow, lymphoid tissue, placenta and intestinal mucosa, physiological hypoxia controls innate and adaptive immunity by modulating immune cell proliferation, development and effector function, largely via transcriptional changes driven by hypoxia-inducible factor (HIF). By contrast, in pathological immunological niches, such as tumours and chronically inflamed, infected or ischaemic tissues, pathological hypoxia can drive tissue dysfunction and disease development through immune cell dysregulation. Here, we differentiate between the effects of physiological and pathological hypoxia on immune cells and the consequences for immunity and inflammation in different immunological niches. Furthermore, we discuss the possibility of targeting hypoxia-sensitive pathways in immune cells for the treatment of inflammatory disease.
Subfields: Cancer Research, Immunology
View Paper: https://www.semanticscholar.org/paper/9a462e4e26e201e1d030838a406a7be83220b869
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
Citations in the corpus
- Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology (2020, background): “…include those which are inflamed, infected or tumour burdened, where hypoxia is common place, as well as those tissues which experience persistent low levels of oxygenation (so called ‘physiological hypoxia’), such as the bone marrow, placenta or gastrointestinal tract (Taylor & Colgan, 2017).”
- Type I conventional dendritic cells and CD8+ T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients (2024, background): “…the response of HNSCC to radiotherapy by regulating i) the survival, proliferation, differentiation, and antitumor capacity of T cells; ii) the survival, migration, antigen presentation, and differentiation of DCs; or iii) the macrophage polarization and tumor development, among others (64, 65).”