p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

By E. Flores, K. Tsai, D. Crowley, Shomit Sengupta, A. Yang, F. McKeon, T. Jacks. Nature, 2002

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How researchers see this paper

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Decision making by p53: life, death and cancer (2003, background): “A rather unexpected insight into p53 promoter selectivity was provided by experiments involving mice rendered null for the p53 homologues p63 and p73.(43) Surprisingly, these”
Apoptosis - the p53 network (2003, background): “A novel insight into the interplay between p53 and its family members, p63 and p73, in the induction of apoptosis has been recently revealed by Flores et al. (Flores et al., 2002).”
Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes (2003, background): “Studies using mouse embryo fibroblasts, lacking either p63 or p73 or bearing a p63/p73 double knockout, indicate that in response to genotoxic stress both p63 and p73 make significant contributions to the apoptotic response in a p53 wild-type background (Flores et al., 2002).”
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, neutral): “In this regard, conventional genetic analysis can fail to uncover important biological functions among closely-related gene families, such as Rb/p107/p130 (Lee et al., 1996; Sage et al., 2000) and p53/p63/p73 (Flores et al., 2002; 2005).”
Control of apoptosis by p53 (2003, background): “Yet, these cells do not recruit p53 to apoptosis-specific promoters and are unable to activate p53-responsive genes linked to apoptosis (Flores et al., 2002).”