Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics.

By Thomas J. Webster, C. Ergun, R. Doremus, R. W. Siegel, R. Bizios. Journal of Biomedical Materials Research, 2000

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Protein Adsorption to Biomaterials (2009, background): “... composite made from nanocrystal hydroxyapatite mixed with PLLA promoted increased protein adsorption from fetal bovine serum as a function of increased nano-HA weight percentage content in the range 10–70% [26, 28] . Studies of the adhesion of osteoblasts on nanophase hydroxyapatite, titania, an”
The interaction of cells and bacteria with surfaces structured at the nanometre scale. (2010, background): “Moreover, vitronectin and fibronectin were shown to be unfolded to a greater extent than on conventional materials exposing larger numbers of adhesive epitopes [210,211].”
Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering. (2004, background): “Recent research demonstrated that cell adhesion and survival could be modulated by protein pre-adsorption on the substrate [25–28].”
Engineering biocompatible implant surfaces (2013, background): “Supporting evidence of decreased fibroblast function on nanophase ceramics has been presented [276–278].”