Functionalized carbon nanotubes for plasmid DNA gene delivery.

By Davide Pantarotto, Ravi Singh, D. McCarthy, M. Erhardt, J. Briand, M. Prato, Kostas Kostarelos, A. Bianco. Angewandte Chemie, 2004

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Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. (2007, neutral): “209" language="eng" relation="no" origsrc="yes"> Water-soluble f -CNTs interact with mammalian cells, leading to their cytoplasmic translocatio”
Carbon nanotubes as nanomedicines: from toxicology to pharmacology. (2006, background): “Also from our laboratories, the work developed regarding the use of CNT as gene therapy vectors [2,33] and drug delivery systems [5,34] have shown that these engineered structures can effectively transport the genes and drugs inside mammalian cells.”
Can the properties of carbon nanotubes influence their internalization by living cells (2008, background): “[24] Pantarotto D, Singh R, McCarthy D, Erhardt M, Briand JP, Prato M, et al.”
Carbon Nanotubes in Biology and Medicine: In vitro and in vivo Detection, Imaging and Drug Delivery (2009, positive): “ translocated into cells by nanotubes, proteins can become bioactive once they are released from endosomes [33] . CNTs can be modified with positive charges to bind DNA plasmids for gene transfection [27, 28, 29, 30]. Pantarotto et al. and Singh et al. used amine-terminated SWNTs and MWNTs functiona”