The molecular landscape of head and neck cancer

By C. R. Leemans, P. Snijders, Ruud H. Brakenhoff. Nature Reviews. Cancer, 2018

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Type I conventional dendritic cells and CD8+ T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients (2024, background): “Therefore, novel biomarkers as well as improved tools to predict therapeutic success and individualize treatment modalities are urgently needed to optimize therapy ef ﬁ cacy, properly adjust therapeutic regimens, and prevent over-or under-treatment with side effects or treatment failure (13).”
Comprehensive Transcriptome Analysis Reveals the Distinct Gene Expression Patterns of Tumor Microenvironment in HPV-Associated and HPV-Non Associated Tonsillar Squamous Cell Carcinoma (2023, background): “…(hr-HPV), primarily HPV-16, HPV 31, HPV 18, HPV 56, HPV 52, HPV 33, and HPV 35, as well as other hr-HPV genotypes [8,9], placing tonsilla squamous cell carcinoma (TSCC) as the most invasive of the oropharyngeal cancers, accounting for more than 23% of all oropharyngeal malignancies [7,10,11].”