Patterns of cortical reorganization in complex regional pain syndrome

By C. Maihöfner, H. Handwerker, B. Neundörfer, F. Birklein. Neurology, 2003

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Patterns of cortical reorganization parallel impaired tactile discrimination and pain intensity in complex regional pain syndrome (2006, background): “The amount of this cortical reorganization appeared to be linked to complaints of CRPS pain: low pain was linked to small hemispherical side-to-side differences, while subjects with a distinctive asymmetry reported the highest pain levels (Maihöfner et al., 2003; Pleger et al., 2004).”
Mental imagery of speech: linking motor and perceptual systems through internal simulation and estimation (2012, background): “Lost limbs cause reorganization in both motor (Maihöfner et al., 2007) and somatosensory (Maihöfner et al., 2003) cortices, and pain reduction has been demonstrated to correlate with more granular organization in the same areas (MacIver et al., 2008).”
Chronic pain may change the structure of the brain. (2008, background): “In patients suffering from chronic regional pain syndrome (CRPS Typ I), a shrinkage of the representational field of the affected arm was found and the extent of shrinkage correlated highly with the intensity of pain and the magnitude of mechanical hyperalgesia [48,59].”