C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway.
By Elizabeth R Sawin, R. Ranganathan, H. Horvitz. Neuron, 2000
1,073 citations recorded by the source corpus.
Subfields: Aging, Ecology, Endocrine and Autonomic Systems
View Paper: https://www.semanticscholar.org/paper/9890b8946d5274f5e43d998ea01682c6de7cb8ff
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Citations in the corpus
- OpenWorm: an open-science approach to modeling Caenorhabditis elegans (2014, background): “This behavioral adaptation is achieved through a dopaminergic neural circuit (Sawin et al., 2000; Omura et al., 2012).”
- Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “Dopamine is known to be required in the modulation of locomotion and in learning in C. elegans (Hills et al., 2004; Sanyal et al., 2004; Sawin et al., 2000).”
- The G‐protein γ subunit gpc‐1 of the nematode C.elegans is involved in taste adaptation (2002, background): “Furthermore, the animals show altered responses to speci®c stimuli such as temperature (Bargmann and Mori, 1997), odorants (Colbert and Bargmann, 1997) and food (Sawin et al., 2000), as a result of changes in their environment or past experience.”
- High-Throughput Behavioral Analysis in C. elegans (2011, background): “Chemosensory mutants also preferentially aggregated on food, perhaps because they, as wild-type worms, can slow down when they reach foo”
- Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease (2011, background): “…in C. elegans is the loss of basal slowing response, a characteristic dopaminedependent reduction of bending frequency when near food (e.g. bacteria), to facilitate feeding (Sawin et al., 2000), but other behaviours such as coiling and freezing have also been noted (Braungart et al., 2004).”
- Chemosensation in C. elegans. (2006, background): “The most important source of serotonin for this behavior is the NSM pharyngeal neurons, which may signal the presence of food in the pharynx to the rest of the animal (Ranganathan et al., 2001; Sawin et al., 2000).”