Halogen atoms in the modern medicinal chemistry: hints for the drug design.

By M. Hernandes, S. Cavalcanti, D. Moreira, W. F. de Azevedo Junior, A. Leite. Current Drug Targets, 2010

605 citations recorded by the source corpus.

Subfields: Computational Theory and Mathematics, Organic Chemistry, Physical and Theoretical Chemistry

View Paper: https://www.semanticscholar.org/paper/988f5666c4e05ea0bd6dcb4e7f1de600dd91fe68

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In Organic Chemistry

1. L. Jones

Citations in the corpus

• Developing irreversible inhibitors of the protein kinase cysteinome (2013, positive): “…an interaction between the chlorine on the pyrimidine of the inhibitors with the methionine gatekeeper, an interaction that has been termed a ‘‘halogen bond,’’ results in the inhibitors possessing selectivity for T790M versus wild-type EGFR (Figure 3D) (Hernandes et al., 2010).”