Tumor Infiltrating CD8+ and Foxp3+ Lymphocytes Correlate to Clinical Outcome and Human Papillomavirus (HPV) Status in Tonsillar Cancer

By A. Näsman, Mircea Romanitan, Cecilia Nordfors, Nathalie Grün, H. Johansson, L. Hammarstedt, L. Marklund, E. Munck-Wikland, T. Dalianis, T. Ramqvist. 2012

Subfields: Cancer Research, Immunology, Otorhinolaryngology

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1. M. Knebel
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5. S. Wemmert
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7. R. Bohle
8. B. Schick

Citations in the corpus

• Prognostic impact of intra- and peritumoral immune cell subpopulations in head and neck squamous cell carcinomas – comprehensive analysis of the TCGA-HNSC cohort and immunohistochemical validation on 101 patients (2023, background): “the interaction of cytotoxic T cells with FoxP3+ regulatory T cells as represented by the CD8/FoxP3 ratio (43), one can even enhance the robustness and validity of CD8+ T cells as biomarker for beneficial clinical outcome in head and neck cancer (43, 45, 46).”