Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear…

By A. Kunnumakkara, S. Guha, Sunil Krishnan, P. Diagaradjane, J. Gelovani, Bharat B. Aggarwal. Cancer Research, 2007

616 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/988172edbbb94852200510015b59f5120a5f84bd

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Citations in the corpus

Targets of curcumin (2011, background): “Curcumin can downregulate the expression and the activity of COX-2 both in vitro and in vivo [169,170].”
Curcumin as "Curecumin": from kitchen to clinic. (2008, background): “[144] Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB.”
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications (2020, background): “…(Pavithra et al., 2009), anti-inflammatories (Nandal et al., 2009), with certain cytotoxic drugs, with chemotherapy (Aggarwal et al., 2005; Kamat et al., 2007; Kunnumakkara et al., 2007; Lin et al., 2007), or when diet supplies contain other polyphenol derivatives (Strimpakos and Sharma, 2008).”
Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment. (2014, background): “In another study, it was shown that the combination of curcumin and gemcitabine significantly down-regulated the expression of the cell proliferation marker Ki-67 in tumor tissues of nude mice indicating a chemosensitizing effect of curcumin [187].”
Curcumin: Preventive and Therapeutic Properties in Laboratory Studies and Clinical Trials (2008, positive): “Curcumin may inhibit angiogenesis directly and via regulation of the growth factors, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), endothelial growth factor (EGF), as well as the genes, angiopoietin 1 & 2,HIF-1,HO-1 , and the transcriptional factors ( e.g ., NF-(cid:4) B”