Intratumor heterogeneity: evolution through space and time.
By Charles Swanton. Cancer Research, 2012
909 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/980af053f25aad626e456acd2e4ae278a062bdd5
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In Cancer Research
In Molecular Biology
In Oncology
Citations in the corpus
- Tree inference for single-cell data (2016, neutral): “Therefore, a more comprehensive understanding of the genetic diversity of individual tumors and their evolutionary history is likely to be a key component in the design of personalized cancer therapies that are more effective [6, 10, 11].”
- Imaging Intratumor Heterogeneity: Role in Therapy Response, Resistance, and Clinical Outcome (2014, background): “Cancerous cells not only undergo clonal evolution from a single progenitor cell into more aggressive and therapy-resistant cells, but also exhibit branched evolution, whereby each tumor develops and preserves multiple distinct subclonal populations (1).”
- Current Challenges in Cancer Treatment. (2016, background): “This was also found in the study by Gerlinger et al(51) and similar reports in other solid tumors that suggest that despite high levels of tumor heterogeneity, recurrent targets and driver mutations are dominant and present in every tumor clone and tumor region, representing robust therapeutic targe”
- Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA (2015, background): “Temporal heterogeneity may occur by linear evolution or by competition between different subclones in the same tumor that compete with each other for dominance during the disease course or under pressure from targeted therapies [11].”
- stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues (2020, background): “However, tissues represent enormously complex cellular ecosystems characterised by local cell type composition, cell distribution, and cell-cell interactions 2–4 .”
- Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. (2015, background): “Accumulating evidence suggests that not every mutation, whether driver or passenger, will be found in every cancer cell within a tumor (see reviews Swanton, 2012; Yates and Campbell, 2012).”