Clopidogrel for Coronary Stenting Response Variability, Drug Resistance, and the Effect of Pretreatment Platelet Reactivity
By P. Gurbel, K. Bliden, B. L. Hiatt, C. O'connor. Circulation, 2003
1,676 citations recorded by the source corpus.
Subfields: Cardiology and Cardiovascular Medicine, Hematology
View Paper: https://www.semanticscholar.org/paper/97f2602e66c8438baf9a1f02a5b4ebbba74780d9
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In Cardiology and Cardiovascular Medicine
Citations in the corpus
- Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation. (2008, methodology): “The wide inter-individual variability in the inhibitory effect of clopidogrel has been well described.(1,4,31) We performed an ROC analysis on a cohort of patients undergoing PCI with DES to (i)”
- Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. (2006, neutral): “Minor bleeding events 12 (29) 17 (44) 19 (51) 22 (48) 12 (32) Venipuncture site bruise 1 (2) 0 (0) 1 (3) 2 (4) 4 (11) Epistaxis 1 (2) 4 (10) 4 (11) 8 (17) 2 (5) Contusion 5 (12) 9 (23) 9 (24) 12 (26) 8 (22) Red blood cells in urine 3 (7) 0 (0) 4 (11) 0 (0) 1 (3) Dyspnoea 4 (10) 4 (10) 6 (16) 9 (20) ”
- Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. (2010, methodology): “Another actor that must be considered is that antiplatelet therapy esponsiveness has been reported to improve over time followng PCI, which may result in lower on-treatment platelet eactivity (6).”
- Variability in platelet responsiveness to clopidogrel among 544 individuals. (2005, result): “We were not able to identify any clinical haracteristics associated with hyper-responsiveness or hyoresponsiveness, nor were we able to confirm the results of revious investigators who reported a relationship between aseline platelet activity and response to clopidogrel (6).”