In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid.

By Yuki Sato, S. Itagaki, T. Kurokawa, Jiro Ogura, Masaki Kobayashi, T. Hirano, M. Sugawara, K. Iseki. International journal of pharmaceutics, 2011

921 citations recorded by the source corpus.

Dietary polyphenols are thought to be beneficial for human health as antioxidants. Coffee beans contain a common polyphenol, chlorogenic acid. Chlorogenic acid is the ester of caffeic acid and quinic acid. Although these polyphenols have received much attention, there is little evidence indicating a relationship between the effect and the rate of absorption. In this study, we focused on the beneficial effects of chlorogenic acid and caffeic acid, a major metabolite of chlorogenic acid. We carried out in vitro and in vivo experiments. In the in vitro study, caffeic acid had stronger antioxidant activity than that of chlorogenic acid. The uptake of chlorogenic acid by Caco-2 cells was much less than that of caffeic acid. The physiological importance of an orally administered compound depends on its availability for intestinal absorption and subsequent interaction with target tissues. We then used an intestinal ischemia-reperfusion model to evaluate antioxidant activities in vivo. We found that both chlorogenic acid and caffeic acid had effects on intestinal ischemia-reperfusion injury. Since caffeic acid has a stronger antioxidant activity than that of chlorogenic acid and chlorogenic acid is hydrolyzed into caffeic acid in the intestine, it is possible that caffeic acid plays a major role in the protective effect of chlorogenic acid against ischemia-reperfusion injury.

Subfields: Nutrition and Dietetics, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/97cfc24d42ce26a84edc1aca94e2af968dc31ebd

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Citations in the corpus

• Breeding for chlorogenic acid content in eggplant: interest and prospects. (2013, background): “Dietary polyphenols from numerous plant species have shown to be beneficial for human health due to its known biological activities, which include free-radical scavenging, regulation of enzymatic activity, and modulation of several cell signaling pathways (Sato et al., 2011).”
• The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature (2017, background): “Several mechanisms have emerged on how chlorogenic acid decreases blood pressure, including the stimulation of NO production through the endothelial-dependent pathway, the reduction of free radicals through inhibiting NAD(P)H oxidase expression and activity, and inhibition of angiotensin-converting ”