Insect olfactory receptors are heteromeric ligand-gated ion channels

By Koji Sato, M. Pellegrino, Takao Nakagawa, Tatsuro Nakagawa, Leslie B. Vosshall, K. Touhara. Nature, 2008

1,096 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Insect Science

View Paper: https://www.semanticscholar.org/paper/97b389694aa062a16440fd24df623068dee88004

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Evolution of insect olfaction. (2011, positive): “Orco acts as a chaperone (Larsson et al., 2004) and also takes part in signal transduction (Sato et al., 2008; Wicher et al., 2008).”
The Olfactory System (2014, background): “…and pharmacological studies using heterologous cells demonstrated that the insect ORs indeed formed heteromeric ligand-gated cation channels (Sato et al. 2008; Wicher et al. 2008) and that both subunits contribute to the formation of channel pore structure (Nakagawa et al. 2012).”
Common Sense about Taste: From Mammals to Insects (2009, background): “The closest relatives of the Grs are the insect odorant receptors, which have recently been proposed to function as ion channels (Sato et al., 2008; Wicher et al., 2008).”
Olfactory information processing in Drosophila. (2009, neutral): “Two recent studies [13,14] have proposed that Or83b contributes to an odorantgated cation channel, although they differ as to whether this is directly odorant-gated or relies on an intermediate”
Mini review: Mode of action of mosquito repellents (2013, background): “They are comprised of a variable odorant-sensing subunit (ORx) and an obligatory and invariable OR co-receptor (Orco) that form ORx-Orco [14–16].”
Non-Canonical Odor Coding in the Mosquito (2020, background): “, 2008) that are formed by a heteromultimeric complex of the conserved co-receptor Orco and a ligand-sensitive OR (Benton et al., 2006; Larsson et al., 2004; Neuhaus et al., 2005; Sato et al., 2008).”
Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors (2015, neutral): “Channel properties depend upon both ORCO and the tuning OR, indicating that both subunits contribute to formation of the ion conducting passage 18, 20, 41, 42 .”
Variant ionotropic glutamate receptors as chemosensory receptors in Drosophila. (2009, positive): “All olfactory sensory neurons (OSNs) innervating basiconic and trichoid sensilla generally express one OR, along with the OR83b coreceptor (reviewed in Vosshall and Stocker, 2007).”