Functional brown adipose tissue in healthy adults.

By K. Virtanen, Martin E. Lidell, Janne Orava, Mikael Heglind, R. Westergren, Tarja Niemi, M. Taittonen, J. Laine, N. Savisto, S. Enerbäck and 1 more. New England Journal of Medicine, 2009

3,056 citations recorded by the source corpus.

Subfields: Biochemistry, Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/979d6721159586c8a9654e1bfb5ed192ec2cbad4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Spiegelman
2. E. Rosen
3. P. Seale
4. Beth Levine
5. H. Ohno
6. A. Suomalainen
7. Jun Wu
8. Sushil Kumar Jain

In Cell Biology

1. Beth Levine
2. N. Mizushima
3. B. Spiegelman
4. Jun Wu
5. E. Rosen
6. Kosaku Shinoda
7. E. Wagner
8. P. Seale

In Physiology

1. B. Spiegelman
2. S. Kajimura
3. P. Seale
4. L. Sidossis
5. E. Rosen
6. Beth Levine
7. Mitchell A. Lazar
8. N. Mizushima

Citations in the corpus

• Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes. (2012, positive): “Given the “rediscovery” of brown adipocytes in adult humans (33–36), and the intense interest surrounding their biology and therapeutic implications, our results imply that the NPs add another dimension to how this tissue may be regulated.”
• Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. (2013, neutral): “There has been revitalized interest in BAT after the discovery of functional BAT in human adults in 2009 (1, 2, 13), not in the least because BAT activation may be able to counteract obesity and type 2 diabetes (27, 29).”
• PPAR agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein (2012, positive): “The thermogenic activity of this tissue correlates inversely with overall adiposity, raising the possibility that variation in the amount or activity of BAT may contribute to the propensity for weight gain in humans (Cypess et al., 2009; Nedergaard et al., 2007; Saito et al., 2009; van Marken Lichte”
• Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist (2015, methodology): “One appealing new target for treatment is the activation of brown adipose tissue (BAT), an organ recently found to be functional in adult humans (van Marken Lichtenbelt et al., 2009; Cypess et al., 2009; Virtanen et al., 2009; Zingaretti et al., 2009; Saito et al., 2009).”