Infection Associated with Prosthetic Joints

By J. L. Del Pozo, Robin Patel. New England Journal of Medicine, 2009

712 citations recorded by the source corpus.

A 62-year-old woman with osteoarthritis presents with a 7-month history of progressively worsening left hip pain radiating to the groin, 8 months after undergoing total left-hip arthroplasty. The pain has not responded to nonsteroidal antiinflammatory drugs. Physical examination reveals a sinus tract overlying her left hip. Her leukocyte count is 8000 per cubic millimeter, and the C-reactive protein (CRP) level is 15.5 mg per liter. A radiograph shows loosening of the prosthesis at the bone–cement interface. Synovial-fluid aspirate shows 15×103 cells per cubic millimeter (89% neutrophils); cultures of an aspirate from the hip grow Staphylococcus epidermidis. How should her case be managed?

Subfields: Epidemiology, Surgery

View Paper: https://www.semanticscholar.org/paper/9781cdc0035328d17494acb3ad91d5107e528767

Citations in the corpus

• Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, neutral): “The majority of PJIs occur in the first year after implantation and are typically caused by commensal microorganisms that were inoculated during surgery (Del Pozo & Patel, 2009).”