Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: differential responses related to surface properties.

By D. Warheit, T. Webb, K. L. Reed, S. Frerichs, Christie M. Sayes. Toxicology, 2007

650 citations recorded by the source corpus.

Subfields: Health, Toxicology and Mutagenesis, Materials Chemistry, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/97649f77fe34d3496e55aef60ff7b9da72a6e3ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Health, Toxicology and Mutagenesis

1. L. Reijnders
2. Vincent Castranova
3. G. Oberdörster

In Materials Chemistry

1. Bengt Fadeel
2. A. Garcia‐Bennett
3. P. Biswas
4. Jingkun Jiang
5. G. Oberdörster
6. L. Reijnders
7. Sumit Arora
8. Wahajuddin

In Public Health, Environmental and Occupational Health

1. Bengt Fadeel

Citations in the corpus

• Titanium dioxide nanoparticles: a review of current toxicological data (2013, background): “this increased catalytic activity to TiO2 NPs to their high surface area, while others attribute it to TiO2 NPs being predominantly anatase rather than rutile [18,19].”
• Evaluating the Control Banding Nanotool: a qualitative risk assessment method for controlling nanoparticle exposures (2009, background): “anatase [ rutile) that is the toxic differential and that surface area alone is not enough to address pulmonary exposure (Liao et al. 2008; Warheit et al. 2007b ).”
• Occupational exposure to titanium dioxide (2011, background): “In a pulmonary toxicity study in rats, the surface activity of the TiO 2 particle (related to crystal structure, passivation, and acidity) was associated with the inflammation and cell proliferation responses at early time points, but not at the later time points [Warheit et al. 2007].”
• Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “Titania nanoparticles of various sizes have been extensively studied in recent years andmay be considered as benchmark particles against which other particles can be compared [103,104].”
• Characterization of size, surface charge, and agglomeration state of nanoparticle dispersions for toxicological studies (2009, background): “In many toxicological studies, the IS of the buffer solution to disperse nanoparticles for in vitro and in vivo tests is often higher than 0.1 M (Long et al. 2006; Warheit et al. 2007; Sager et al. 2007; Murdock et al. 2008).”
• The release of TiO2 and SiO2 nanoparticles from nanocomposites (2009, background): “[8,16,75,76], may in turn affect hazard [1,48,49,51,67,77].”