Closed-loop stimulation of temporal cortex rescues functional networks and improves memory
By Youssef Ezzyat, P. Wanda, Deborah F. Levy, Allison Kadel, Ada Aka, Isaac Pedisich, M. Sperling, A. Sharan, B. Lega, Alexis Burks and 12 more. Nature Communications, 2018
299 citations recorded by the source corpus.
Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction. Memory lapses can occur due to ineffective encoding, but it is unclear if targeted brain stimulation can improve memory performance. Here, authors use a closed-loop system to decode and stimulate periods of ineffective encoding, showing that stimulation of lateral temporal cortex can enhance memory.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/97647d3c1c8b7821ed81526ecf8b26bd12e01814
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
- Nikolai Axmacher
- Cory S. Inman
- Mostyn W. Jones
- Simon Hanslmayr
- Tam Hunt
- Justin Riddle
- F. H. Lopes da Silva
Citations in the corpus
- Why does invasive brain stimulation sometimes improve memory and sometimes impair it? (2024, unknown): “…of stimulation protocols could go further, including patient-specific customization based on the task, and phase of memory processing, frequency of neural oscillations, and adjusting stimulation parameters accordingly such that stimulation is applied in a real-time, closed-loop fashion [36,53,112].”
- Fields or firings? Comparing the spike code and the electromagnetic field hypothesis (2023, background): “Fiebelkorn et al. (2018) are especially helpful here because their review paper spells out in detail how theta rhythms help organize attention processes.”
- Modulating Human Memory via Entrainment of Brain Oscillations. (2019, background): “Furthermore, closed-loop stimulation in which the stimulation parameters are adjusted to neural oscillations in real-time have high promise to dissociate between different oscillatory mechanisms in the service of memory [71].”