Antimicrobial chitosan–PVA hydrogel as a nanoreactor and immobilizing matrix for silver nanoparticles

By S. Agnihotri, S. Mukherji, S. Mukherji. Applied Nanoscience, 2012

172 citations recorded by the source corpus.

Hydrogels are water-insoluble crosslinked hydrophilic networks capable of retaining a large amount of water. The present work aimed to develop a novel chitosan–PVA-based hydrogel which could behave both as a nanoreactor and an immobilizing matrix for silver nanoparticles (AgNPs) with promising antibacterial applications. The hydrogel containing AgNPs were prepared by repeated freeze–thaw treatment using varying amounts of the crosslinker, followed by in situ reduction with sodium borohydride as a reducing agent. Characterization studies established that the hydrogel provides a controlled and uniform distribution of nanoparticles within the polymeric network without addition of any further stabilizer. The average particle size was found to be 13 nm with size distribution from 8 to 21 nm as per HR-TEM studies. Swelling studies confirmed that higher amount of crosslinker and silver incorporation inside the gel matrices significantly enhanced the porosity and chain entanglement of the polymeric species of the hydrogel, respectively. The AgNP-hydrogel exhibited good antibacterial activity and was found to cause significant reduction in microbial growth (Escherichia coli) in 12 h while such activity was not observed for the hydrogel without AgNPs.

Subfields: Biomaterials, Materials Chemistry, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/97590f386220528a4709511f3ccb1ff1940299ae

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In Biomaterials

1. C. Liao
2. S. Tjong
3. Yuchao Li

In Materials Chemistry

1. C. Liao
2. S. Tjong
3. Yuchao Li
4. Dimitris Bikiaris

In Surfaces, Coatings and Films

1. C. Liao
2. S. Tjong
3. Yuchao Li

Citations in the corpus

• Bactericidal and Cytotoxic Properties of Silver Nanoparticles (2019, methodology): “In the latter case, metal salt is dissolved in aqueous polymer solution, followed by in situ reduction with sodium borohydride and freeze-thawing cycles [126,127].”