Ferroptosis: molecular mechanisms and health implications
By D. Tang, Xin Chen, R. Kang, Guido Kroemer. Cell Research, 2020
3,607 citations recorded by the source corpus.
Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis. Ferroptosis can occur through two major pathways, the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Ferroptosis is caused by a redox imbalance between the production of oxidants and antioxidants, which is driven by the abnormal expression and activity of multiple redox-active enzymes that produce or detoxify free radicals and lipid oxidation products. Accordingly, ferroptosis is precisely regulated at multiple levels, including epigenetic, transcriptional, posttranscriptional and posttranslational layers. The transcription factor NFE2L2 plays a central role in upregulating anti-ferroptotic defense, whereas selective autophagy may promote ferroptotic death. Here, we review current knowledge on the integrated molecular machinery of ferroptosis and describe how dysregulated ferroptosis is involved in cancer, neurodegeneration, tissue injury, inflammation, and infection.
Subfields: Cancer Research, Molecular Biology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/97559e1f64dabcaa9a989bc868717dca64d17db5
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In Pulmonary and Respiratory Medicine
Citations in the corpus
- Copper metabolism in cell death and autophagy (2023, background): “Ferroptosis can be caused by both intrinsic and extrinsic pathways [129,130].”
- Ferroptosis in infection, inflammation, and immunity (2021, background): “The ambiguous role of ferroptosis in tumor immunity alsomeans that manipulation of the ferroptotic pathway for tumor treatment is still challenging and requires careful evaluation (Chen et al., 2021b).”
- Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis (2022, background): “Ferroptosis has attracted considerable interest because of its potential role as a target for novel therapeutic anticancer strategies and these interactions with infections [89].”