Gut microbiota and IBD: causation or correlation?
By Josephine Ni, Gary D. Wu, L. Albenberg, V. Tomov. Nature Reviews Gastroenterology &Hepatology, 2017
1,512 citations recorded by the source corpus.
A general consensus exists that IBD is associated with compositional and metabolic changes in the intestinal microbiota (dysbiosis). However, a direct causal relationship between dysbiosis and IBD has not been definitively established in humans. Findings from animal models have revealed diverse and context-specific roles of the gut microbiota in health and disease, ranging from protective to pro-inflammatory actions. Moreover, evidence from these experimental models suggest that although gut bacteria often drive immune activation, chronic inflammation in turn shapes the gut microbiota and contributes to dysbiosis. The purpose of this Review is to summarize current associations between IBD and dysbiosis, describe the role of the gut microbiota in the context of specific animal models of colitis, and discuss the potential role of microbiota-focused interventions in the treatment of human IBD. Ultimately, more studies will be needed to define host–microbial relationships relevant to human disease and amenable to therapeutic interventions.
Subfields: Genetics, Infectious Diseases, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/973729f85d5aa2822e55b4f1c3ccc25a51be473e
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Citations in the corpus
- Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome (2019, background): “inhibition of colonic inflammation [48] (Figure 1).”
- A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease (2019, background): “However, in human, it is difficult to demonstrate a definitive cause-effect relationship between intestinal microbiota and IBD [36].”
- Microbiota in health and diseases (2022, background): “The possible role of fungi and viruses in IBD are also being studied and reviewed, but no link has been established thus far.(234,245) While most of the studies are focusing on gut microbiota, oral microbiota is gaining attention with the characterization of the oral-gut axis.”