Inflammation in atrial fibrillation.
By Yutao Guo, Gregory Y. H. Lip, S. Apostolakis. Journal of the American College of Cardiology, 2012
831 citations recorded by the source corpus.
Atrial fibrillation (AF) is associated with increased risk for stroke and systemic embolism. There is plausible evidence linking inflammation to the initiation and perpetuation of AF and AF-related thrombosis. Various inflammatory markers (C-reactive protein, tumor necrosis factor-α, interleukin-2, interleukin-6, and interleukin-8) have been associated with AF. Proposed mechanisms linking inflammation and the prothrombotic AF state include endothelial activation/damage, production of tissue factor from monocytes, increased platelet activation, and increased expression of fibrinogen. The present review aims to provide an update on the association of inflammation and AF, including the impact of inflammatory markers on clinical presentation and outcome of AF patients.
Subfields: Cardiology and Cardiovascular Medicine, Epidemiology, Internal Medicine
View Paper: https://www.semanticscholar.org/paper/971a8525588bf49942916f423178f0df4bc3cb7f
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In Cardiology and Cardiovascular Medicine
In Internal Medicine
Citations in the corpus
- EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. (2016, positive): “Pro-inflammatory stimuli such as NOX-derived ROS, growth factors, and other hormones has been demonstrated to have a role in Ang-II function.(253) However, the precise molecular modifications of the putative signalling targets of ROS after Ang-II stimulation are yet to be identified.”