Interface-Driven Hybrid Materials Based on DNA-Functionalized Gold Nanoparticles

By Biwu Liu, Juewen Liu. Matter, 2019

163 citations recorded by the source corpus.

DNA-functionalized gold nanoparticles (AuNPs) are popular hybrid materials with applications in directed assembly, biosensor development, and drug delivery. This system is particularly interesting due to the versatile optical and catalytic properties of AuNPs combined with the molecular recognition and programmable properties of DNA. Instead of emphasizing applications, this review focuses on the interfaces including adsorption of thiol and DNA bases, colloidal stability of AuNPs, and related methods for preparing this conjugate. The effects of salt, pH, proteins, and DNA base composition are discussed for controlling the conformation, density, and stability of DNA. Hybridization of DNA on AuNPs, DNA-directed growing of materials, and cellular uptake of this conjugate are discussed as examples to highlight the importance of the interfaces. Our understanding of these biointerfaces is still far from complete, and a few future research opportunities for engineering hybrid materials are described.

Subfields: Electronic, Optical and Magnetic Materials, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/96e6e500a12dba64f8ee2dcc040c6587eaa37ad3