Insulin resistance and cardiovascular disease.

By H. Ginsberg. Journal of Clinical Investigation, 2000

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Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. (2013, background): “Specifically, small, dense LDL particles, which are increased in insulin-resistant or obese patients, are the source of oxidized LDL and can enter the vascular wall, which facilitates the development of atherosclerosis [80,81].”
Cardiovascular Effects and Benefits of Exercise (2018, background): “The association between blood lipids and cardiovascular health is highly influenced by systemic insulin sensitivity, and resistance to insulin signaling is known to promote the development of heart disease, in part by altering the blood lipid profile (31).”
Pathophysiology of Type 2 Diabetes Mellitus (2020, background): “This highly atherogenic lipid profile is a pivotal contributor to atherogenic dyslipidemia, which is causally linked to the development and progression of atherosclerotic CV disease (ASCVD) [233,234].”