Understanding the potential for resistance evolution to the new herbicide pyroxasulfone: Field selection at high doses versus recurrent selection at low doses

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Diverse Approaches to Herbicide-Resistant Weed Management (2016, background): “The occurrence of glyphosate resistance was enhanced when low dosages were used in rigid ryegrass populations and the response of these populations to paraquat was also reduced (Busi et al. 2012; Busi and Powles 2009, 2011).”
ACCase-inhibiting herbicides: mechanism of action, resistance evolution and stewardship (2021, background): “Mechanisms of weed resistance to ACCase inhibitors Weeds resistance to ACCase inhibitors have significant economic relevance especially due to the limited number of herbicides with alternative MoAs, and their role in managing GR monocot weeds in postemergence.”
Herbicide Metabolism: Crop Selectivity, Bioactivation, Weed Resistance, and Regulation (2019, background): “Metabolic resistance to pyroxasulfone was experimentally evolved from a population that already had metabolic resistance to ACCase, ALS, and mitosis inhibitors (Busi et al. 2012), but no pyroxasulfone resistance evolved following repeated selection on a susceptible population.”