A Randomized Controlled Trial of Metformin versus Vitamin E or Prescriptive Diet in Nonalcoholic Fatty Liver Disease

By E. Bugianesi, E. Gentilcore, R. Manini, S. Natale, E. Vanni, N. Villanova, E. David, M. Rizzetto, Giulio Marchesini. American Journal of Gastroenterology, 2005

689 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9642670647bd15d46a677dc7bd767570bbcd602a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. Z. Younossi
2. M. Rinella
3. K. Cusi
4. C. Day
5. A. Sanyal
6. S. Bellentani
7. G. Targher
8. Megan H. Bair-Merritt

In Epidemiology

1. Z. Younossi
2. M. Rinella
3. A. Sanyal
4. K. Cusi
5. E. Brunt
6. C. Day
7. S. Bellentani
8. J. Lavine

In Molecular Biology

1. M. Rinella

Citations in the corpus

• The Diagnosis and Management of Non-alcoholic Fatty Liver Disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association (2012, methodology): “An open-label trial consisting of 110 patients with NASH received either metformin 2 grams/day (55 patients), vitamin E 800 IU/day (28 patients) or dietary-induced weight loss (27 patients) for 12 months.(109) Aminotransferases improved more with metformin than with vitamin E or diet alone.”
• Pathogenesis of non-alcoholic fatty liver disease (2009, background): “Several clinical studies of antioxidants such as vitamin E, which have been shown to suppress fibrosis in vitro, have so far failed to demonstrate that dietary supplementation of vitamin E improves histological fibrosis in humans.(110,111) A large number of cytokines are intimately involved in the p”
• The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases (2018, background): “A liver biopsy to establish a diagnosis of NASH should be obtained before starting children on pharmacological therapy for NASH.”
• A position statement on NAFLD/NASH based on the EASL 2009 special conference. (2010, background): “There are several small negative trials with vitamin E [211,221,222]; however, in a larger randomized trial 800 IU/day improved all histological lesions except for fibrosis [207].”