Clearance Pathways and Tumor Targeting of Imaging Nanoparticles

By Mengxiao Yu, Jie Zheng. ACS Nano, 2015

780 citations recorded by the source corpus.

A basic understanding of how imaging nanoparticles are removed from the normal organs/tissues but retained in the tumors is important for their future clinical applications in early cancer diagnosis and therapy. In this review, we discuss current understandings of clearance pathways and tumor targeting of small-molecule- and inorganic-nanoparticle-based imaging probes with an emphasis on molecular nanoprobes, a class of inorganic nanoprobes that can escape reticuloendothelial system (RES) uptake and be rapidly eliminated from the normal tissues/organs via kidneys but can still passively target the tumor with high efficiency through the enhanced permeability permeability and retention (EPR) effect. The impact of nanoparticle design (size, shape, and surface chemistry) on their excretion, pharmacokinetics, and passive tumor targeting were quantitatively discussed. Synergetic integration of effective renal clearance and EPR effect offers a promising pathway to design low-toxicity and high-contrast-enhancement imaging nanoparticles that could meet with the clinical translational requirements of regulatory agencies.

Subfields: Biomaterials, Biomedical Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/95b16e560510a572e13d690a83f7b5365e5a6469

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. Wilson Poon
  2. Yi-Nan Zhang
  3. I. McGilvray
  4. Warren C. W. Chan

Citations in the corpus