Reward-motivated learning: mesolimbic activation precedes memory formation.

By R. Alison Adcock, A. Thangavel, Susan L. Whitfield-Gabrieli, Brian Knutson, John D. E. Gabrieli. Neuron, 2006

976 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/9501920cd97a6f1cde5f163dbaaa23593910db52

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Anticipatory affect: neural correlates and consequences for choice (2008, neutral): “Adcock et al. (2006) x Bjork et al. (2004)AB xxxx”
Item, context and relational episodic encoding in humans. (2006, background): “Consistent with a purported role for PhC in encoding of spatial context, fMRI studies using pictures of landscapes as memoranda [35–39] or those asking subjects to imagine a spatial layout corresponding with a word [7,18], have reported SM effects in the PhC.”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, positive): “, 2006; Schultz, 1998), DA does play an important role in memory encoding in the hippocampus (Adcock et al., 2006; Gasbarri et al., 1996; Hersi et al., 1995; Li et al., 2003; Lisman and Grace, 2005; Wittmann et al., 2005) and amygdala (Bissiere et al.”
Post-learning hippocampal dynamics promote preferential retention of rewarding events (2016, positive): “…resonance imaging (fMRI) studies in humans have shown that reward motivation enhances memory encoding and is associated with increased activity in, and interactions between, the SN/VTA and the hippocampus (Adcock et al., 2006; Murty and Adcock, 2014; Wittmann et al., 2005; Wolosin et al., 2012).”
Integrating Memories in the Human Brain: Hippocampal–Midbrain Encoding of Overlapping Events (2008, methodology): “Such outcomes would add to a growing body of evidence indicating a broader role for this system in learning and memory by modulating the hippocampus, in addition to the striatum (Adcock et al., 2006; Lisman and Grace, 2005; Wittmann et al., 2005).”
Selectivity in Postencoding Connectivity with High-Level Visual Cortex Is Associated with Reward-Motivated Memory (2017, background): “Similarly, in humans, the anterior hippocampus has been reliably associated with the successful encoding of motivationally relevant memoranda compared with neutral memoranda (Dolcos et al., 2004; Adcock et al., 2006; Murty et al., 2010; Poppenk et al., 2013).”
The Reward Circuit: Linking Primate Anatomy and Human Imaging (2010, background): “In addition, midbrain increases in activation have been reported in response to reward-predicting cues (Adcock et al , 2006; Wittmann et al , 2005), and this activation, in concert with medial temporal lobe activation, predicts subsequent enhancements in memory for associated stimuli.”
Modulation of aesthetic value by semantic context: An fMRI study (2009, positive): “Other findings suggest that midbrain dopaminergic systems involved in reward expectation could directly modulate declarative memory formation in the hippocampus ( Adcock et al., 2006; Bernabeu et al.,1997; Wittmann et al., 2005).”
States of curiosity modulate hippocampus-dependent learning via the dopaminergic circuit (2014, positive): “…that between-individual variations in activity in the SN/VTA and hippocampus predicted memory benefits for unrelated, neutral faces, it is reasonable to speculate that these relationships were driven by functional connectivity between the two regions (Adcock et al., 2006; Wolosin et al., 2012).”