Sp1- and Krüppel-like transcription factors

By Joanna A. Kaczynski, T. Cook, R. Urrutia. Genome Biology, 2003

989 citations recorded by the source corpus.

SummarySp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that are important components of the eukaryotic cellular transcriptional machinery. By regulating the expression of a large number of genes that have GC-rich promoters, Sp1-like/KLF transcription regulators may take part in virtually all facets of cellular function, including cell proliferation, apoptosis, differentiation, and neoplastic transformation. Individual members of the Sp1-like/KLF family can function as activators or repressors depending on which promoter they bind and the coregulators with which they interact. A long-standing research aim has been to define the mechanisms by which Sp1-like factors and KLFs regulate gene expression and cellular function in a cell- and promoter-specific manner. Most members of this family have been identified in mammals, with at least 21 Sp1-like/KLF proteins encoded in the human genome, and members are also found in frogs, worms and flies. Sp1-like/KLF proteins have highly conserved carboxy-terminal zinc-finger domains that function in DNA binding. The amino terminus, containing the transcription activation domain, can vary significantly between family members.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/94ee31d5cc34050121ae96a0ac499636c1aa4445

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Citations in the corpus

• Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “…CTCF, c-Myc, n-Myc, STAT3, and Zfx are closely related to the binding sequences reported previously (Ehret et al., 2001; Galan-Caridad Cell 133, 1106–1117, June 13, 2008 ª2008 Elsevier Inc. 1107 et al., 2007; Kaczynski et al., 2003; Kim et al., 2007; Pettersson et al., 1996; Zeller et al., 2006).”
• Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis (2009, background): “Krüppel-like factor 9 (Klf-9) is a member of the Krüppel-like factor (Klf) family of evolutionarily conserved zinc finger transcription factors (Kaczynski et al., 2003) that has been implicated in mediating a diverse range of biological processes including stem cell maintenance (Jiang et al.”