Viral and host factors related to the clinical outcome of COVID-19

By Xiaonan Zhang, Yun Tan, Y. Ling, G. Lu, Feng Liu, Zhigang Yi, Xiaofang Jia, Min Wu, Bisheng Shi, Shuibao Xu and 15 more. Nature, 2020

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The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19 (2020, neutral): “The main contributing features explaining this difference included IL8 (Figure 2B), a chemokine recently shown to be associated with lymphopenia in severe COVID-19 cases (Zhang et al., 2020).”
Severe Covid-19. (2020, background): “[18] Severe COVID-19 has been associated with a cytokine release storm largely related to the ACE-2.”
Predictors of COVID-19 severity: A literature review (2020, background): “2 The precise determinants of severe disease are not known, but it appears that primarily host factors rather than viral genetic mutations drive the pathogenesis.(3) However, emerging data from a non-peer-reviewed”
Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19 (2020, positive): “, 2020) and the degree of lymphopenia has been correlated with increases in circulating interleukin-6 (IL-6) and IL-8 (Zhang et al., 2020).”