The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

By J. MacArthur, Emily Bowler, M. Cerezo, Laurent Gil, Peggy Hall, Emma Hastings, Heather Junkins, A. McMahon, Annalisa Milano, Joannella Morales and 7 more. 2016

2,060 citations recorded by the source corpus.

The NHGRI-EBI GWAS Catalog has provided data from published genome-wide association studies since 2008. In 2015, the database was redesigned and relocated to EMBL-EBI. The new infrastructure includes a new graphical user interface (www.ebi.ac.uk/gwas/), ontology supported search functionality and an improved curation interface. These developments have improved the data release frequency by increasing automation of curation and providing scaling improvements. The range of available Catalog data has also been extended with structured ancestry and recruitment information added for all studies. The infrastructure improvements also support scaling for larger arrays, exome and sequencing studies, allowing the Catalog to adapt to the needs of evolving study design, genotyping technologies and user needs in the future.

Subfields: Genetics, Molecular Biology

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Citations in the corpus

A standardized framework for representation of ancestry data in genomics studies, with application to the NHGRI-EBI GWAS Catalog (2018, background): “Human genomics studies, including GWAS, have been enormously successful [3, 5, 26].”
The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 (2018, background): “uk/gwas; (16)) is a publicly available resource of published human GWAS.”
Sequential regulatory activity prediction across chromosomes with convolutional neural networks (2017, methodology): “The set includes 12,296 biallelic SNPs taken from the NIH GWAS Catalog database (MacArthur et al. 2017) and a negative”
Bringing the Animal QTLdb and CorrDB into the future: meeting new challenges and providing updated services (2021, background): “In addition to Animal QTLdb, a number of databases have incorporated QTL/association data for a variety of species, including human (10,11), rat (12), mouse (13), crops (14– 18), model plants (19) and others.”
DrugBank 5.0: a major update to the DrugBank database for 2018 (2017, background): “org and FDA labels), as well as material collated from sources such as The Human Cytochrome P450 (CYP) Allele Nomenclature Database (12) and the NHGRI-EBI GWAS Catalog (13).”