Drug delivery systems: An updated review

By G. Tiwari, R. Tiwari, Birendra Sriwastawa, L. Bhati, S. Pandey, P. Pandey, S. Bannerjee. International Journal of Pharmaceutical Investigation, 2012

1,314 citations recorded by the source corpus.

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. For the treatment of human diseases, nasal and pulmonary routes of drug delivery are gaining increasing importance. These routes provide promising alternatives to parenteral drug delivery particularly for peptide and protein therapeutics. For this purpose, several drug delivery systems have been formulated and are being investigated for nasal and pulmonary delivery. These include liposomes, proliposomes, microspheres, gels, prodrugs, cyclodextrins, among others. Nanoparticles composed of biodegradable polymers show assurance in fulfilling the stringent requirements placed on these delivery systems, such as ability to be transferred into an aerosol, stability against forces generated during aerosolization, biocompatibility, targeting of specific sites or cell populations in the lung, release of the drug in a predetermined manner, and degradation within an acceptable period of time.

Subfields: Pharmaceutical Science, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/93f8d2c9c9a08c210655becc15eab3dba017403e

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1. T. C. Ezike
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Citations in the corpus

• Applications of nanoparticle systems in drug delivery technology (2017, background): “There are two geometric isomers of resveratrol (cis- and trans), however the more abundant and bioactive trans-resveratrol, is photosensitive, converters to cis-resveratrol in the presence of light (Trela and Waterhouse, 1996).”
• Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview (2018, background): “In order to provide a specific therapeutic effect in human or animal organisms, it is essential to consider the process or method applied during the administration of the selected pharmaceutical compound [86].”
• pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications (2017, background): “Currently, researchers are focusing on improving the efficacy ratio of existing drugs due to the high cost and xten ive time involved in the synth sis of ew drugs [137].”
• Advances in drug delivery systems, challenges and future directions (2023, background): “Over the last 60 years, there has been a lot of focus on developing controlled and well reliable drug delivery systems [82].”
• Review of Multifarious Applications of Poly (Lactic Acid) (2016, methodology): “Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals([125]).”
• A Review on Recent Advancements of Graphene and Graphene-Related Materials in Biological Applications (2021, background): “The most investigated biological application of graphene and related materials’ still remains drug delivery [91].”