Linking Structure and Function in Macroscale Brain Networks.

By Laura E. Suárez, Ross D. Markello, Richard F. Betzel, Bratislav Misic. Trends in Cognitive Sciences, 2020

710 citations recorded by the source corpus.

Structure-function relationships are a fundamental principle of many naturally occurring systems. However, network neuroscience research suggests that there is an imperfect link between structural connectivity and functional connectivity in the brain. Here, we synthesize the current state of knowledge linking structure and function in macroscale brain networks and discuss the different types of models used to assess this relationship. We argue that current models do not include the requisite biological detail to completely predict function. Structural network reconstructions enriched with local molecular and cellular metadata, in concert with more nuanced representations of functions and properties, hold great potential for a truly multiscale understanding of the structure-function relationship.

Subfields: Cognitive Neuroscience, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/93dbc4cec621bcd0d9b85d01200101649a0b4a02

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In Cognitive Neuroscience

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex (2021, background): “A key question in neuroscience remains how the brain’s structural architecture gives rise to its function [6, 122].”