A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.

By Jin-zhou Huang, Min Chen, De Chen, Xing-cheng Gao, Song Zhu, Hongyang Huang, Min Hu, Huimeng Zhu, Guang-Rong Yan. Molecules and Cells, 2017

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LNCcation: lncRNA localization and function (2021, background): “A substantial number of annotated lncRNAs have recently been identified to encode small peptides (Anderson et al., 2015; Chen et al., 2020; Huang et al., 2017; Matsumoto et al., 2017; Nelson et al., 2016; Rossi et al., 2019; Stein et al., 2018; van Heesch et al., 2019); however, that lncRNA associat”
UniProt: the Universal Protein Knowledgebase in 2023 (2022, background): “…both the sequence quality and annotation content of the human proteome, recu-rating sequences that are inconsistent, and creating records describing the products of newly identified protein-coding genes, such as micropeptides identified in what were thought to be long non-coding RNAs (21,22).”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “It is translated from the lncRNA HOXB-AS3 and was shown to suppress colon cancer growth; its loss is a critical oncogenic event in metabolic reprogramming 129 .”