Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis

By G. Disanto, Christian Barro, P. Benkert, Y. Naegelin, Sabine Schädelin, Antonella Giardiello, C. Zecca, Kaj Blennow, Henrik Zetterberg, D. Leppert and 18 more. Annals of Neurology, 2017

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Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations. We explored the value of an ultrasensitive single‐molecule array (Simoa) serum NfL (sNfL) assay in multiple sclerosis (MS).

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/93a6569ec91a43c8e71bbda655e14ff3266ecc30